案例：患者，男，32岁。头昏，乏力2年，血压21.3/13.3kPa(160/100mmHg)，血红蛋白80g/L，尿比重1.014，尿蛋白（++)，颗粒管型0-2/HP，BUN16.4mmol/L(46mg/dl)，血肌酐309.4μmol/L(3.5mg/dl)，眼底视网膜动脉细窄迂曲。可能性最大的诊断是

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