A leukemia that shows a profusion of granulocytes at all stages of development，with the majority of cells being myelocytes and segmented neutrophils，is

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• 1A common characteristic of acute lymphocytic leukemia is

  A.a leukemia of older persons

  B.bone and joint pain

  C.many blast cells with Auer rods

  D.leykocytopenia

  E.many blast cells with positive POX stain

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• 2Chromosome changes in hematologic neoplasms are

  A.present in AL but not MPD or MDS

  B.nonrandom

  C.associated with a poor outcome

  D.not usually present

  E.associated with a good outcome

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• 3Auer rods are inclusions found in

  A.myelobfasts

  B.lymphoblasts

  C.erythrocytes

  D.prolymphocytes

  E.megakaryocytes

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• 4The FAB classification is used to divide acute leukemias into groups according to

  A.immunology

  B.clinical presentation

  C.cytogenetics

  D.morphology

  E.molecular phenotype

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• 5Immunologic phenotyping of the blast cells is important to

  A.help determine cell lineage

  B.identify the etiology of the leukemia

  C.determine if cytogenetic analysis is necessary

  D.replace the need to do multiple cytochemical stains

  E.replace the morphologic detection

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• 6The most prominent cell line in CML is the

  A.erythroid

  B.myeloid

  C.megakaryocyte

  D.fibroblast

  E.lymphoid

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• 7The Philadelphia chromosome is a gene fusion from a translocation of

  A.chromosomes 8 and 14

  B.chromosomes 9 and 22

  C.chromosomes 12 and 17

  D.chromosomes 15 and 17

  E.chromosomes 11 and 17

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• 8Molecular analysis by RT-PCR revealed the presence of a BCR/ABL fusion product.Based on this information，what myeloproliferative disorders is present

  A.CML

  B.PV

  C.ET

  D.MMM

  E.MDS

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• 9Which of the following is not typical of an MPD at the time of diagnosis

  A.hypercellular bone marrow

  B.anemia

  C.leukoerythroblastosis

  D.predominance of blasts in peripheral blood

  E.hepatosplenomegaly

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• 10下列关于造血干细胞，叙述错误的是

  A.绝大多数表达CD34

  B.低表达或不表达HLA-DR

  C.多数细胞处于G0期或静止期

  D.缺乏特异系列抗原表面标志

  E.是一类失去自我更新能力的细胞群

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