医药学论文：糖尿病肾病肾阴虚证与内皮素-1相关性的临床研究

【中文摘要】 [目的] 研究糖尿病肾病肾阴虚证患者与内皮素-1的相关性。探索肾阴虚证客观诊断指标。为证的客观化、标准化、规范化作贡献。 [方法] 运用病证结合的方法，选择临床上糖尿病肾病肾阴虚证患者为研究对象，设糖尿病肾病肾阳虚证患者及正常人为对照组，用放免法检测其血浆内皮素-1(ET-1)含量的变化。分析二证患者与正常人之间血浆内皮素-1水平的差异。同时对肾阴虚证及肾阳虚证所辖症状进行程度量化，最后累计各项得分，即其证候积分，对证候积分与ET-1 水平进行直线相关分析，探求两变量之间有无相关性及相关度的大小。 [结果] 糖尿病肾病肾阴虚证组患者ET-1含量明显高于肾阳虚证组患者及正常人组(均为p＜0.01)；糖尿病肾病肾阳虚证组患者血浆ET-1含量明显高于正常人组(p＜0.05)。肾阴虚证患者血浆ET-1水平与证候积分呈正相关(r=0.76，p＜0.05)；肾阳虚证患者血浆ET-1水平与证候积分呈负相关(r=-0.83，p＜0.05)；ET-1水平与患者年龄、病程无相关性。 [结论] ET-1水平可作为肾虚证辨

【英文摘要】 [Object i ve] : To observe the correlation between the Daibetic Nephropathy kidney-yin deficiency and ET-1.To research the objectivity diagnosis guideline of the kidney-Yin deficiency. To do some work for diagnosis, standardization, and norm as well. [Method] : Utilizing the method of combination for syndrome and disease, selecting the patients of the Daibetic Nephropathy kidney- yin deficiency as the research groups , the Daibetic Nephropathy kidney patients of Kindey-Yang deficiency and normal person as c