医药学论文：丽珠肠乐和氟西汀合用治疗腹泻型肠易激综合征的疗效观察

【关键词】 ,丽珠肠乐

　　摘 要：目的：研究丽珠肠乐和氟西汀合用治疗腹泻型肠易激综合征（IBS）的临床疗效。方法：对54例腹泻型肠易激综合征病人随机分为治疗组30例和对照组24例，治疗组口服丽珠肠乐胶囊0.7g（2粒）,每日2次，氟西汀胶囊10mg，每日2次，用8周。对照组口服丽珠肠乐胶囊0.7g，每日2次，用8周。结果:治疗组完全缓解14例（46.7%），部分缓解12例（40%），不缓解4例（13.3%），总有效率为86.7%，对照组完全缓解4例（16.7%）,部分缓解11例（45.8%），不缓解9例（37.5%），总有效率为62.5%，两组有明显差异（P＜0.05）。结论:丽珠肠乐和氟西汀合用治疗腹泻型肠易激综合征疗效好，副作用少，尤其适用于伴有明显心理障碍的病人。

　　关键词： 腹泻型肠易激综合征； 丽珠肠乐； 氟西汀

　　Observe the Curative Effect of Livzon Bifidobacterium Preparation and Fluoxetine on Diarrehea-predominant　Pattern Irritable Bowel Syndrome

　　Abstract：Objective：To investigate the curative effect of livzon bifidobacterium preparation and fluoxetine on irritable bowel syndrome.Methods：54 patients with diarrehea-predominant pattern irritable bowel syndrome were enrolled in this study.The patients were divided into two groups:30 patients in curative group and 24 patients in control group.The patient of curative group takes livzon bifidobacterium preparation capsule 0.7g,b.i.d,and fluoxetine capsule 10mg,b.i.d.for 8 weeks .The patient of control group takes livzon bifidobacterium preparation capsule 0.7g,b.i.d.for 8 weeks.Results： In the curative group 14 patients were complete remission(46.7%),12 patients were part remission(40%),4 patients were not remission(13.3%).The total effective rate are 86.7%.In the control group 4 patients were remission(16.7%),11 patients were part remission (45.8%),9 patients were not remission(37.5%).The total effective rate was 62.5%.The two groups have significant differences（p＜0.05）.Conclusion： The effect of Livzon bifidobacterium preparation and fluoxetine on diarrehea-predominant pattern irritable bowel syndrome is good.The two medicine have little side effect and especially for patients psychological block.

　　Key words： Diarrehea-predominant pattern irritable bowel syndrome; Livzon bifidobacterium preparation; Fluoxetine

　　我院1999年至2004年间门诊及内科病房共收治腹泻型IBS病人54例，其中30例病人予以丽珠肠乐和氟西汀合用治疗取得了较好的疗效，现分析如下：

　　1 材料与方法

　　1．1 一般web/bbs/index.htm' target=_blank>资料：本组54例均符合罗马Ⅱ标准，并经生化检查、内镜、B超、X线或CT等影像学检查，排除器质性疾病。所有病人都表现为腹痛、大便次数增多、稀便或水样便，部分病人有焦虑，抑郁和睡眠障碍，病程3个月至10余年。将54例病人随机分为两组，治疗组30例，其中男性14例，女性16例，年龄22～65岁，平均43.5岁。对照组24例，其中男性10例，女性14例，年龄20～68岁，平均44岁。