医药学论文：肾康注射液与苯那普利对肾小球系膜基质作用的对比研究

内容提要　目的：探讨肾康注射液与苯那普利对人肾小球系膜细胞外基质(ECM)不同成分的抑制作用强度。方法：采用体外培养的人肾小球系膜细胞技术，观察具有降逆泄浊、益气活血功效的中药肾康注射液及苯那普利对ECM不同成分的影响。结果：肾康注射液具有抑制ECM成分中纤维连接蛋白(FN)、层粘连蛋白(LN)和Ⅳ型胶原(Col Ⅳ)的作用，该抑制作用具有一定的量效关系。苯那普利对ECM中FN、Col Ⅳ也有一定的抑制作用，但不及肾康注射液作用明显。结论：肾康注射液对ECM的抑制作用优于苯那普利。

　　Objective: To explore the intensity of inhibition of Shenkang Injection (SKI) and Benazepril on various ingredients of human glomerular mesangial extracellular matrix (ECM).Methods: Effect of SKI, a herbal preparation for lowering adverse Qi, despelling turbidness, supplementing Qi and activating circulation, and Benazepril were observed by cultured glomerular mesangial cell technique in vitro.Results: SKI could inhibit the fibronetin, laminin, and type Ⅳ collagen of ECM, and the action was dose-dependent. Benazepril could also inhibit the fibronetin and type Ⅳ collagen of ECM but was weaker in intensity.Conclusion: The effect of SKI was superior to Benazepril in inhibiting ECM. Ⅳ collagen of ECM, and the action was dose-dependent. Benazepril could also inhibit&nb sp;the fibronetin and type Ⅳ collagen of ECM but was weaker in intensity.Conclusion: The effect of SKI was superior to Benazepril in inhibiting ECM.